Who doesn't love Oprah? She’s beautiful, funny, and totally memeable. Premiering on March 7th, 2021, the special interview with Prince Harry and Meghan Markle blew up instantly. From the honest and open interview, the audience went crazy over Oprah’s reaction to Prince Harry’s and Meghan Markle's candid answers. The meme-worthy content that Oprah gave us was hilarious. Her relatable expressions drove the internet insane; we just can't get enough of her!